Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines

ABSTRACT In patients with invasive fungal diseases, there is often little cellular inflammatory response. We tested the idea that binding of the human constitutive plasma protein serum amyloid P component (SAP) (also called PTX2) to Candida albicans dampens the innate immune response to this fungus....

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Autori principali:	Nicole E. Behrens, Peter N. Lipke, Darrell Pilling, Richard H. Gomer, Stephen A. Klotz
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2019-04-01
Serie:	mBio
Soggetti:	SAP cytokines functional amyloid innate immunity macrophage polarization
Accesso online:	https://journals.asm.org/doi/10.1128/mBio.00218-19
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