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In vitro size-selection of short circulating tumor DNA fragments from late-stage lung cancer patients enhance the detection of mutations and aneuploidies

Introduction: Recent studies have demonstrated differences between the fragment length profiles of cell-free DNA (cfDNA) from cancer patients and healthy individuals. This has led to the development of in vitro size-selection procedures which can isolate the short fragments that are enriched with mu...

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Main Authors: Christoffer Trier Maansson, Louise Skov Thomsen, Laura Stokkebro, Julie Gabe Dissing, Maiken Parm Ulhoi, Anders Lade Nielsen, Peter Meldgaard, Boe Sandahl Sorensen
Format: Artigo
Language:Inglês
Published: Elsevier 2024-06-01
Series:The Journal of Liquid Biopsy
Subjects:
Liquid biopsy
Size-selection
NGS
Lung cancer
Fragmentomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2950195424000067
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