Vaccinia virus for lung cancer therapy: preclinical progress and prospects as a systemic immunotherapy platform

Lung cancer remains a major therapeutic challenge, particularly when tumors resist targeted therapy or checkpoint blockade. Vaccinia virus (VV), historically used as a vaccine vector, is now being repurposed to selectively kill tumor cells while activating antitumor immunity. Beyond direct oncolysis...

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Hlavní autoři:	Linkai Li, Zhongyu Chen, Yunrui Yan, Lening Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-05-01
Edice:	Frontiers in Immunology
Témata:	immunotherapy lung cancer oncolytic virotherapy preclinical and clinical studies tumormicroenvironment vaccinia virus
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797922/full
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