Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles

Selective serotonin reuptake inhibitors (SSRIs) are less efficacious in treating depression in children than in adults. SSRIs block serotonin uptake via the high-affinity, low-capacity serotonin transporter. However, the low-affinity, high-capacity organic cation transporter 3 (OCT3) and plasma memb...

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Autors principals:	Melodi A. Bowman, Jorge A. Gomez, Nathan C. Mitchell, Anne M. Wells, Melissa Vitela, Kyra M. Clarke, Rebecca E. Horton, Wouter Koek, Lynette C. Daws
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-08-01
Col·lecció:	Cells
Matèries:	antidepressant decynium-22 depression juvenile organic cation transporter 3 plasma membrane monoamine transporter
Accés en línia:	https://www.mdpi.com/2073-4409/11/15/2454
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