Cytoplasmic MSH2 Related to Genomic Deletions in the MSH2/EPCAM Genes in Colorectal Cancer Patients With Suspected Lynch Syndrome

BackgroundA large proportion of patients with Lynch syndrome (LS) have MSH2 abnormalities, but genotype-phenotype studies of MSH2 mutations in LS are still lacking. The aim of this study was to comprehensively analyze the clinicopathological characteristics and molecular basis of colorectal cancer (...

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Detalhes bibliográficos

Principais autores:	Lin Dong, Shuangmei Zou, Xianglan Jin, Haizhen Lu, Ye Zhang, Lei Guo, Jianqiang Cai, Jianming Ying
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Oncology
Assuntos:	DNA mismatch repair Lynch syndrome colorectal cancer genetic testing immunotherapy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2021.627460/full
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