Transposable elements as a possible missing link between genetic predisposition and environmental triggers of autoimmune disorders: insights from type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis

Transposable elements (TEs) make up almost half of the human genome and are among its most densely methylated regions. Their epigenetic silencing is crucial for genomic stability and immune homeostasis, and accumulating evidence indicates that dysregulated TE methylation and expression contribute to...

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Hlavní autoři:	Karolina Mužina, Ana Markež Vrhovšek, Barbara Jenko Bizjan, Neja Šamec, Jernej Kovač, Klemen Dovč, Tadej Battelino, Marko Pokorn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-04-01
Edice:	Frontiers in Immunology
Témata:	autoimmune disease autoimmunity epigenetic methylation RNA-seq sequencing
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1774863/full
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