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Di-(2-ethylhexyl) phthalate induces spermatogenic dysfunction via p38/NCOA4-dependent ferritinophagy and ferroptosis in Sertoli cells

Di-(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental endocrine disruptor that leaches from polyvinyl chloride products and metabolizes to mono-(2-ethylhexyl) phthalate (MEHP), causing spermatogenic dysfunction in males.However, the molecular mechanism linking DEHP/MEHP to Sertoli cell da...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Anni Feng, Yuanjie Xie, Qiong Wang, Zhongcheng Mo, Baijun Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2026-05-01
Schriftenreihe:Ecotoxicology and Environmental Safety
Schlagworte:
DEHP
Spermatogenesis disorders
Sertoli cells
Ferroptosis
Ferritinophagy
NCOA4
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S0147651326004835
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