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Functionalized Folate-Modified Graphene Oxide/PEI siRNA Nanocomplexes for Targeted Ovarian Cancer Gene Therapy

Abstract Gene therapy is emerging as a valid method for the treatment of ovarian cancer, including small interfering RNA (siRNA). Although it is so powerful, few targeting efficient gene delivery systems seriously hindered the development of gene therapy. In this study, we synthesized a novel gene v...

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Principais autores: Yunfei Wang, Guoping Sun, Yingying Gong, Yuying Zhang, Xiaofei Liang, Linqing Yang
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2020-03-01
coleção:Nanoscale Research Letters
Assuntos:
Ovarian cancer
Folate
GO
Target
Gene therapy
Lysosomal escape
Acesso em linha:http://link.springer.com/article/10.1186/s11671-020-3281-7
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