A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway

Abstract Background The largest dengue virus 2 (DENV2) outbreak occurred in Taiwan in 2015, resulting in many fatalities. We therefore aim to identify crucial genetic variations which determine the virulence of the 2015 Taiwan outbreak strains. Methods We compared the 2015 Taiwan DENV2 sequences to...

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Bibliographic Details

Main Authors:	Jing-Ru Hee, Dayna Cheng, Yu-Hong Chen, Sheng-Hsuan Wang, Chiao-Hsuan Chao, Sheng-Wen Huang, Pin Ling, Shu-Wen Wan, Chih-Peng Chang, Justin Jang Hann Chu, Trai-Ming Yeh, Jen-Ren Wang
Format:	Artigo
Language:	Inglês
Published:	BMC 2025-02-01
Series:	Journal of Biomedical Science
Subjects:	Dengue virus Non-structural protein 1 Type I interferon Pro-inflammatory cytokines
Online Access:	https://doi.org/10.1186/s12929-024-01116-4
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