Physiological and Pathological Brain Activation in the Anesthetized Rat Produces Hemodynamic-Dependent Cortical Temperature Increases That Can Confound the BOLD fMRI Signal

Anesthetized rodent models are ubiquitous in pre-clinical neuroimaging studies. However, because the associated cerebral morphology and experimental methodology results in a profound negative brain-core temperature differential, cerebral temperature changes during functional activation are likely to...

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Detalhes bibliográficos

Principais autores:	Samuel S. Harris, Luke W. Boorman, Devashish Das, Aneurin J. Kennerley, Paul S. Sharp, Chris Martin, Peter Redgrave, Theodore H. Schwartz, Jason Berwick
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-08-01
Colecção:	Frontiers in Neuroscience
Assuntos:	cortical temperature cerebral metabolic rate of oxygen cerebral hemodynamics sensory stimulation hypercapnia seizures
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fnins.2018.00550/full
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