Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors

Abstract Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapies have demonstrated remarkable efficacy in hematologic malignancies; however, their clinical performance in solid tumors remains limited due to suboptimal tumor infiltration, antigen heterogeneity, and immunosuppressive tumor...

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Autori principali:	Yan-Ruide Li, Miao Li, Yuning Chen, Houfu Leng, Yichen Zhu, Xinyuan Shen, Duncan Croll, Enbo Zhu, Jie Huang, Yu-Chen Wang, Abigail S. Krall, Heather R. Christofk, Aldons J. Lusis, Lili Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2026-03-01
Serie:	Signal Transduction and Targeted Therapy
Accesso online:	https://doi.org/10.1038/s41392-026-02602-x
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