Role of endothelin-1 antagonist; bosentan, against cisplatin-induced nephrotoxicity in male and female rats
Background: Cisplatin (CP) is a chemotherapy drug, with the major side effect of nephrotoxicity. The level of endothelin-1 (ET-1) increases during nephrotoxicity, which is accompanied with vasoconstrictive properties. Bosentan (BOS) is a nonselective ET-1 receptor antagonist, having vasodilatory and...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wolters Kluwer Medknow Publications
2015-01-01
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| coleção: | Advanced Biomedical Research |
| Assuntos: | |
| Acesso em linha: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=83;epage=83;aulast=Jokar |
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