Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

Antioxidant systems, such as the thioredoxin-1 (Trx1) pathway, ensure cellular redox homeostasis. However, how such systems regulate development and function of myeloid cells is barely understood. Here we show that in contrast to its critical role in T cells, the murine Trx1 system is dispensable fo...

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Detalhes bibliográficos

Principais autores:	Jonathan Muri, Helen Thut, Qian Feng, Manfred Kopf
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2020-02-01
coleção:	eLife
Assuntos:	nf- kb NLRP3 inflammasome thioredoxin-1 glutaredoxin reactive oxygen species txnip
Acesso em linha:	https://elifesciences.org/articles/53627
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