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Human adipose cells in vitro are either refractory or responsive to insulin, reflecting host metabolic state.

While intercellular communication processes are frequently characterized by switch-like transitions, the endocrine system, including the adipose tissue response to insulin, has been characterized by graded responses. Yet here individual cells from adipose tissue biopsies are best described by a swit...

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Autori principali: Vladimir A Lizunov, Karin G Stenkula, Paul S Blank, Aaron Troy, Jo-Ping Lee, Monica C Skarulis, Samuel W Cushman, Joshua Zimmerberg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2015-01-01
Serie:PLoS ONE
Accesso online:https://doi.org/10.1371/journal.pone.0119291
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