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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Abstract The tumor micro-environment (TME) of hepatocellular carcinoma (HCC) consists out of cirrhotic liver tissue and is characterized by an extensive deposition of extracellular matrix proteins (ECM). The evolution from a reversible fibrotic state to end-stage of liver disease, namely cirrhosis,...

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Autori principali: Carlemi Calitz, Jenny Rosenquist, Oliver Degerstedt, Jaafar Khaled, Maria Kopsida, Mårten Fryknäs, Hans Lennernäs, Ayan Samanta, Femke Heindryckx
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2023-01-01
Serie:Scientific Reports
Accesso online:https://doi.org/10.1038/s41598-023-27997-3
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