Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme

Abstract CAR T-cell therapy has transformed relapsed/refractory (r/r) B-cell precursor acute lymphoblastic leukaemia (B-ALL) management and outcomes, but following CAR T infusion, interventions are often needed. In a UK multicentre study, we retrospectively evaluated tisagenlecleucel outcomes in all...

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Principais autores:	Macarena Oporto Espuelas, Saskia Burridge, Amy A. Kirkwood, Denise Bonney, Kelly Watts, Geoff Shenton, Katarzyna A. Jalowiec, Maeve A. O’Reilly, Claire Roddie, Anna Castleton, Katherine Clesham, Emma Nicholson, Rajesh Alajangi, Shilpa Prabhu, Lindsay George, Ben Uttenthal, Maria Gabelli, Lorna Neill, Caroline Besley, Sridhar Chaganti, Robert F. Wynn, Jack Bartram, Robert Chiesa, Giovanna Lucchini, Vesna Pavasovic, Anupama Rao, Kanchan Rao, Juliana Silva, Sujith Samarasinghe, Ajay Vora, Peter Clark, Michelle Cummins, David I. Marks, Persis Amrolia, Rachael Hough, Sara Ghorashian
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2024-04-01
Series:	Blood Cancer Journal
Acceso en liña:	https://doi.org/10.1038/s41408-024-01038-2
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