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Cycloheximide promotes type I collagen maturation mainly via collagen prolyl 4-hydroxylase subunit α2

Aberrant deposition of collagen is associated with cancer development and tissue fibrosis. Proline hydroxylation, catalyzed by collagen prolyl 4-hydroxylases (C-P4Hs), is necessary for collagen maturation and secretion. Here, we try to evaluate the mechanism of the regulation of CHX on collagen matu...

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Библиографические подробности
Главные авторы: Shi Run, Xu Miao, Ye Huazhe, Gao Shanshan, Li Jingfeng, Li Huan, Li Chaoyang
Формат: Artigo
Язык:Inglês
Опубликовано: China Science Publishing & Media Ltd. 2022-12-01
Серии:Acta Biochimica et Biophysica Sinica
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Online-ссылка:https://www.sciengine.com/doi/10.3724/abbs.2022191
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