Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation

PARP2 is a DNA repair protein. The deletion of PARP2 induces mitochondrial biogenesis and mitochondrial activity by increasing NAD⁺ levels and inducing SIRT1 activity. We show that the silencing of PARP2 causes mitochondrial fragmentation in myoblasts. We assessed multiple pathways that c...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Laura Jankó, Tünde Kovács, Miklós Laczik, Zsanett Sári, Gyula Ujlaki, Gréta Kis, Ibolya Horváth, Miklós Antal, László Vígh, Bálint L. Bálint, Karen Uray, Péter Bai
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2021-06-01
Sarja:	Cells
Aiheet:	PARP2 ARTD2 oxidative stress mitochondrial biogenesis skeletal muscle mitochondrial fragmentation
Linkit:	https://www.mdpi.com/2073-4409/10/6/1387
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