Structural basis for the allosteric activation of Lon by the heat shock protein LarA
Abstract Lon is a conserved AAA+ (ATPases associated with diverse cellular activities) proteolytic machine that plays a key regulatory role in cells under proteotoxic stress. Lon-mediated proteolysis can be stimulated by either the unfolded or specific protein substrates accumulated under stress con...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2025-03-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-025-57482-6 |
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