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Synthesis, antileishmanial activity and QSAR studies of 2-chloro- N -arylacetamides

ABSTRACT We describe herein the synthesis and evaluation of the antileishmanial activity against promastigote forms of Leishmania amazonensis and cytotoxicity to murine macrophages of a series of 2-chloro-N-arylacetamide derivatives. All compounds were active, except one (compound 3). Compound 5 pre...

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Main Authors: Stefânia Neiva Lavorato, Mariana Costa Duarte, Pedro Henrique Rocha De Andrade, Eduardo Antonio Ferraz Coelho, Ricardo José Alves
Format: Artigo
Language:Inglês
Published: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2017-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Leishmaniasis/treatment
Chloroacetamides
Leishmania amazonensisChloroacetamides/QSAR.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100620&lng=en&tlng=en
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