A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production

Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB therapy. A small molecule, RG7834, has been previou...

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Hauptverfasser:	Anastasia Hyrina, Christopher Jones, Darlene Chen, Scott Clarkson, Nadire Cochran, Paul Feucht, Gregory Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang, Kyoko Uehara, Lili Xie, Don Ganem, Meghan Holdorf
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2019-12-01
Schriftenreihe:	Cell Reports
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124719314469
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