Withangulatin A Identified as a Covalent Binder to Zap70 Kinase by Molecular Docking
Inhibitors of the tyrosine kinase Zap70 are actively searched to improve treatments of lymphoid malignancies and autoimmune diseases associated with an abnormal T-cell response. The natural product withaferin A (WFA) has been characterized as a covalent inhibitor of Zap70 capable of blocking the mig...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2025-09-01
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| coleção: | Computation |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2079-3197/13/9/207 |
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