Large-scale screening of HBV epitopes restricted by multiple prevalent HLA-B/C allotypes and routine detection of HBV-specific T cells in CHB patients

Background and aimsIn our previous work, a total of 103 CD8+ T-cell epitopes restricted by 13 prevalent HLA-A allotypes in Northeast Asians were validated from the main proteins of hepatitis B virus (HBV). This study aims to further screen the T-cell epitopes restricted by 15 prevalent HLA-B and 14...

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Autors principals:	Yandan Wu, Yu Zhao, Ruixue Ji, Pinqing Li, Huijuan Chen, Fangping Yue, Yi Wu, Jie Qiu, Chuanlai Shen
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-01-01
Col·lecció:	Frontiers in Immunology
Matèries:	ELISpot assay hepatitis B virus HLA-A HLA-B HLA-C T-cell epitope
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1717543/full
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