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Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation

Primary hepatocytes (PHCs) are widely used in various fields, but the progressive deterioration of liver-specific features in vitro significantly limits their application. While the transcriptional regulation and whole cell proteome (WCP) of PHCs have been extensively studied, only a small number of...

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Principais autores: Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020-11-01
Series:Engineering
Assuntos:
Ubiquitination
Phosphoproteome
Proteome
Dedifferentiation
Primary hepatocytes
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2095809920301314
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