Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes.
Evolutionary forces that shape regulatory networks remain poorly understood. In mammals, the Rb pathway is a classic example of species-specific gene regulation, as a germline mutation in one Rb allele promotes retinoblastoma in humans, but not in mice. Here we show that p53 transactivates the Retin...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2012-06-01
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| Serie: | PLoS Genetics |
| Accesso online: | http://europepmc.org/articles/PMC3386156?pdf=render |
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