METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through m6A-YTHDF2-pluripotency/Gstp1 mRNA degradation axis

Abstract N6-methyladenosine (m6A) plays crucial roles in development and cellular reprogramming. During embryonic development, pluripotency transitions from a naïve to a primed state, and modeling the reverse primed-to-naïve transition (PNT) provides a valuable framework for investigating pluripoten...

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Bibliografische Detailangaben

Hauptverfasser:	Sa Li, Jiajie Hao, Guangliang Hong, Hongzhi Dong, He Liu, Lingmei Jin, Zhihao Zhang, Haoyu Wu, Mingli Hu, Rujin Huang, Guanzheng Luo, Jiangping He, Jiekai Chen, Kaixin Wu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SpringerOpen 2025-05-01
Schriftenreihe:	Cell Regeneration
Schlagworte:	METTL3 Primed to Naïve Transition YTHDF2 Gstp1
Online-Zugang:	https://doi.org/10.1186/s13619-025-00241-1
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