HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts

During the 2021/2022 winter season, we isolated highly pathogenic avian influenza (HPAI) H5N1 viruses harbouring an amino acid substitution from Asparagine(N) to Aspartic acid (D) at residue 193 of the hemagglutinin (HA) receptor binding domain (RBD) from migratory birds in South Korea. Herein, we i...

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Bibliografske podrobnosti

Principais autores:	Seung-Gyu Jang, Young-Il Kim, Mark Anthony B. Casel, Jeong Ho Choi, Ju Ryeon Gil, Rare Rollon, Eun-Ha Kim, Se-Mi Kim, Ho Young Ji, Dong Bin Park, Jungwon Hwang, Jae-Woo Ahn, Myung Hee Kim, Min-Suk Song, Young Ki Choi
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis Group 2024-12-01
Serija:	Emerging Microbes and Infections
Teme:	HPAI H5N8 virus Clade 2.3.4.4 reassortant pathogenecity South Korea Influenza infections
Online dostop:	https://www.tandfonline.com/doi/10.1080/22221751.2024.2302854
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