Conservation of human NMDA receptor subunits and disease variants in zebrafish

Abstract Background NMDA receptors (NMDARs) are widely expressed, ligand-gated ion channels that play key roles in brain development and function. Variants have been identified in the GRIN genes encoding NMDAR subunits that are linked to neurodevelopmental disorders, among other manifestations. Zebr...

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Detalhes bibliográficos
Main Authors: Erica R. Nebet, Christieann Aprea, Josiah D. Zoodsma, William J. Raab, Howard I. Sirotkin, Lonnie P. Wollmuth
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
Colecção:BMC Genomics
Assuntos:
GRIN genes
ClinVar
GnomAD
Sequence alignments
Disease-associated variants
N-terminal domain
Acesso em linha:https://doi.org/10.1186/s12864-025-12274-6
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