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Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

Abstract Background Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous data demonstrate that astrocytes ingest large amounts of aggregated amyloid-beta (Aβ), but then store, rath...

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Principais autores: Evangelos Konstantinidis, Benjamin Portal, Tobias Mothes, Chiara Beretta, Maria Lindskog, Anna Erlandsson
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-01-01
coleção:Journal of Neuroinflammation
Assuntos:
Alzheimer’s disease
Amyloid-beta
Astrocytes
Electrophysiology
EPSCs
iPSCs
Acesso em linha:https://doi.org/10.1186/s12974-022-02687-5
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