Vorinostat unmasks MAEL to enhance DC vaccine-induced CTL killing in hepatocellular carcinoma, potentiated by TIGIT checkpoint inhibition

Abstract Background To address the limited immunogenicity and immune evasion in hepatocellular carcinoma (HCC), this study developed a combinatorial immunotherapy strategy combining antigen-specific vaccination, epigenetic modulation, and TIGIT-targeted checkpoint blockade. Methods Bioinformatic scr...

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Auteurs principaux:	Can Liu, Qianru Zhang, Jingjing Zhang, Wenpeng Liu, Shengya Geng, Jiandong Zhang
Format:	Artigo
Langue:	Inglês
Publié:	Springer 2026-05-01
Collection:	Cancer Immunology, Immunotherapy
Sujets:	MAEL antigen Peptide Cytotoxic T lymphocyte Vorinostat TIGIT blocking
Accès en ligne:	https://doi.org/10.1007/s00262-026-04410-2
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