Discovery of potent STAT3 inhibitors using structure-based virtual screening, molecular dynamic simulation, and biological evaluation

IntroductionSignal transducer and activator of transcription 3 (STAT3) is ubiquitously hyper-activated in numerous cancers, rendering it an appealing target for therapeutic intervention.Methods and resultsIn this study, using structure-based virtual screening complemented by molecular dynamics simul...

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Hlavní autoři:	Weifeng Liu, Zhijie Chu, Cheng Yang, Tianbao Yang, Yanhui Yang, Haigang Wu, Junjun Sun
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-11-01
Edice:	Frontiers in Oncology
Témata:	STAT3 structure-based virtual screening molecular docking molecular dynamic simulation gastric cancer
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1287797/full
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