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Nanobodies to GPVI as alternative reagents for platelet spreading

Platelet spreading assays are widely used to assess platelet adhesion, cytoskeletal remodeling and receptor‑specific signaling, but current GPVI ligands such as Collagen Related Peptide (CRP‑XL) suffer from non‑defined structure, batch variability, and high cost. Nanobodies targeting GPVI offer an a...

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Autori principali: Alexandre Slater, Hsin-Yun Pan, Tzu-Han Ho, Eleyna M. Martin, Stephen P. Watson, Jeremy A. Pike, Natalie S. Poulter, Steven G. Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2026-12-01
Serie:Platelets
Soggetti:
CRP-XL
glycoprotein VI (GPVI)
nanobodies
platelet spreading
receptor clustering
Accesso online:https://www.tandfonline.com/doi/10.1080/09537104.2026.2653068
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