Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans

Abstract Background Phosphatidylinositol transfer protein-1 (pitp-1) is involved in the phosphoinositide (PIP) cycle. The role of pitp-1 in promoting healthy longevity remains unknown. Our previous work showed that the PIP cycle–related genes diacylglycerol lipase-1 (dagl-1) and diacylglycerol kinas...

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Príomhchruthaitheoirí:	Yen-Hung Lin, Yun-Hsun Liao, Sin-Bo Liao, Tzu-Yu Lin, Muniesh Muthaiyan Shanmugam, Pei-Jia Hsu, Chang-Shi Chen, Tsiu-Ting Ching, Oliver Ingvar Wagner, Chiou-Hwa Yuh, Horng-Dar Wang
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	BMC 2026-04-01
Sraith:	Journal of Biomedical Science
Ábhair:	Pitp-1 Aging Healthspan Longevity TOR signaling Insulin/igf-1 signaling
Rochtain ar líne:	https://doi.org/10.1186/s12929-026-01246-x
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