The effect of cathepsin K deficiency on airway development and TGF-β1 degradation

<p/> <p>Background</p> <p>Cathepsin K, a cysteine protease predominantly expressed in osteoclasts, is a major drug target for the treatment of osteoporosis. Recent findings, however, indicate that cathepsin K is also involved in non-skeletal metabolism. The development of fibrotic phenotypes in lung...

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Hlavní autoři:	Saftig Paul, Weber Ekkehard, Leung Nelson, Zhang Dongwei, Brömme Dieter
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2011-05-01
Edice:	Respiratory Research
Témata:	lung airway cathepsin K TGF-β1 extracellular matrix protease inhibitors
On-line přístup:	http://respiratory-research.com/content/12/1/72
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