FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity

Lactate dehydrogenase A (LDHA) mediates interconversion of pyruvate and lactate, and increased lactate turnover is exhibited by malignant and infected immune cells. Hypoxic lung granuloma in Mycobacterium tuberculosis-infected animals present elevated levels of Ldha and lactate. Such alterations in...

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Autori principali:	Gopinath Krishnamoorthy, Peggy Kaiser, Ulrike Abu Abed, January Weiner, Pedro Moura-Alves, Volker Brinkmann, Stefan H. E. Kaufmann
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	The Company of Biologists 2020-03-01
Serie:	Disease Models & Mechanisms
Soggetti:	glycolysis lactate dehydrogenase a fx11 mycobacterium tuberculosis granuloma hypoxia immunometabolism host-directed therapy
Accesso online:	http://dmm.biologists.org/content/13/3/dmm041954
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