Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

Influenza virus alters glycosylation patterns on its surface exposed glycoproteins to evade host adaptive immune responses. The viral hemagglutinin (HA), in particular the H3 subtype, has increased its overall surface glycosylation since its introduction in 1968. We previously showed that modulating...

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Principais autores:	Dana N. Thornlow, Andrew N. Macintyre, Thomas H. Oguin, Amelia B. Karlsson, Erica L. Stover, Heather E. Lynch, Gregory D. Sempowski, Aaron G. Schmidt
格式:	Artigo
语言:	Inglês
出版:	Frontiers Media S.A. 2021-10-01
丛编:	Frontiers in Immunology
主题:	influenza hemagglutinin glycans immunogen design adaptive immunity B cells
在线阅读:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.737973/full
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