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The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation.

Because DNA double-strand breaks (DSBs) are one of the most cytotoxic DNA lesions and often cause genomic instability, precise repair of DSBs is vital for the maintenance of genomic stability. Xrs2/Nbs1 is a multi-functional regulatory subunit of the Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex, and its fu...

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Principais autores: Daichi Iwasaki, Kayoko Hayashihara, Hiroki Shima, Mika Higashide, Masahiro Terasawa, Susan M Gasser, Miki Shinohara
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2016-03-01
Serier:PLoS Genetics
Online adgang:http://europepmc.org/articles/PMC4798412?pdf=render
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