Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis

Candida albicans can enter skeletal tissue through a skin wound in an immunocompromised host or by contamination during orthopedic surgery. Such Candida osteomyelitis is accompanied by severe pain and bone destruction. It is established that nociceptor innervation occurs in skin and bone, but the me...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kenta Maruyama, Yasunori Takayama, Takeshi Kondo, Ken-ichi Ishibashi, Bikash Ranjan Sahoo, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M. Martino, Hiroki Tanaka, Naohito Ohno, Yoichiro Iwakura, Naoki Takemura, Makoto Tominaga, Shizuo Akira
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2017-06-01
Schriftenreihe:	Cell Reports
Schlagworte:	Candida albicans β-glucan TRPV1 TRPA1 osteoclast Jdp2 NF-κB
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124717307787
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