Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons

Protein kinase type C-ε (PKCε) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification. In these neurons, PKCε is modulated through the local release of mediators by the sur...

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Detalhes bibliográficos

Principais autores:	Veronica Bonalume, Lucia Caffino, Luca F. Castelnovo, Alessandro Faroni, Flavio Giavarini, Sheng Liu, Donatella Caruso, Martin Schmelz, Fabio Fumagalli, Richard W. Carr, Valerio Magnaghi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-08-01
Colecção:	Cells
Assuntos:	neuro-glia interaction neuropathic pain hyperalgesia dorsal root ganglia neuroactive steroid
Acesso em linha:	https://www.mdpi.com/2073-4409/9/8/1874
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