Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort

Altered cholesterol metabolism is implicated in brain ageing and Alzheimer’s disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer’s disease neuropathological change (ADNC). Temporal cortex (n = 99) was obtained...

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Principais autores:	Hemant Mistry, Connor D. Richardson, Adrian Higginbottom, Bridget Ashford, Saif U. Ahamed, Zoe Moore, Fiona E. Matthews, Carol Brayne, Julie E. Simpson, Stephen B. Wharton
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-07-01
coleção:	Neuroscience Research
Assuntos:	Cholesterol HMG-CoA reductase Sterol regulatory element-binding proteins Dementia Alzheimer’s disease Cognitive Function and Ageing Study
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0168010224000075
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