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Genomic Reporter Constructs to Monitor Pathway-Specific Repair of DNA Double-Strand Breaks

Repair of DNA Double-Strand Breaks (DSBs) can be error-free or highly mutagenic, depending on which of multiple mechanistically distinct pathways repairs the break. Hence, DSB-repair pathway choice directly affects genome integrity, and it is therefore of interest to understand the parameters that d...

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Hlavní autoři: Bert van de Kooij, Haico van Attikum
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-02-01
Edice:Frontiers in Genetics
Témata:
genomic reporter constructs
double-strand break repair pathway choice
homologous recombination
end-joining
single-strand annealing
On-line přístup:https://www.frontiersin.org/articles/10.3389/fgene.2021.809832/full
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