KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray. We generated KLHL41 mutant mice, which display lethal disruption...

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Detalles Bibliográficos

Principais autores:	Andres Ramirez-Martinez, Bercin Kutluk Cenik, Svetlana Bezprozvannaya, Beibei Chen, Rhonda Bassel-Duby, Ning Liu, Eric N Olson
Formato:	Artigo
Idioma:	Inglês
Publicado:	eLife Sciences Publications Ltd 2017-08-01
Series:	eLife
Assuntos:	protein aggregation nebulin Kelch protein nemaline myopathy
Acceso en liña:	https://elifesciences.org/articles/26439
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