Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration

BackgroundLumbar disc degeneration, a primary cause of chronic low back pain, is closely linked to inflammatory responses and the immune microenvironment; however, its underlying mechanisms remain poorly understood.MethodsThis study integrated scRNA-seq and bulk RNA-seq data to identify macrophage s...

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Detalhes bibliográficos

Principais autores:	Hongxing Zhang, Bin Dai, Jiafeng Peng, Minglei Gao, Danyang Li, Xiaowei Xiang, Junchen Zhu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-12-01
coleção:	Frontiers in Immunology
Assuntos:	lumbar disc degeneration single-cell RNA sequencing machine learning immune microenvironment hdWGCNA
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1671961/full
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