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Micro-CT-assisted identification of the optimal time-window for antifibrotic treatment in a bleomycin mouse model of long-lasting pulmonary fibrosis

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a debilitating and fatal lung disease characterized by the excessive formation of scar tissue and decline of lung function. Despite extensive research, only two FDA-approved drugs exist for IPF, with limited efficacy and relevant side effects. Thus, th...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Martina Buccardi, Andrea Grandi, Erica Ferrini, Davide Buseghin, Gino Villetti, Maurizio Civelli, Nicola Sverzellati, Andrea Aliverti, Francesca Pennati, Franco Fabio Stellari
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-06-01
Schriftenreihe:Scientific Reports
Schlagworte:
Bleomycin model
Lung fibrosis
IPF
Drug discovery
Micro-computed tomography
Functional measurements
Online-Zugang:https://doi.org/10.1038/s41598-024-65030-3
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