Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron- and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple he...

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Detalles Bibliográficos

Principais autores:	Piao Luo, Dandan Liu, Qian Zhang, Fan Yang, Yin-Kwan Wong, Fei Xia, Junzhe Zhang, Jiayun Chen, Ya Tian, Chuanbin Yang, Lingyun Dai, Han-Ming Shen, Jigang Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2022-05-01
Series:	Acta Pharmaceutica Sinica B
Assuntos:	Celastrol Ferroptosis Peroxiredoxin HO-1 Hepatic fibrosis ABPP
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211383521004792
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