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Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer

Abstract Background DNA hypomethylation and uracil misincorporation into DNA, both of which have a very important correlation with colorectal carcinogenesis. Folate plays a crucial role in DNA synthesis, acting as a coenzyme in one-carbon metabolism, which involves the synthesis of purines, pyrimidi...

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Autors principals: Meng Ye, Guojie Xu, Liming Zhang, Zhihui Kong, Zhenhua Qiu
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-01-01
Col·lecció:BMC Cancer
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Accés en línia:https://doi.org/10.1186/s12885-025-13546-w
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