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Role of Nrf2/HO-1 and cytoglobin signaling in the protective effect of indole-3-acetic acid and chenodeoxycholic acid against kidney injury induced by valproate

Background: Purpose: Valproate (VPA) is an antiepileptic drug widely used to treat various psychiatric and neurological disorders. Although its use is generally considered safe, chronic administration may lead to kidney injury. The mechanisms underlying VPA kidney toxicity are not entirely explored....

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Principais autores: Ahlam M. Alhusaini, Wedad Sarawi, Noor Mukhtar, Danah Aljubeiri, Amjad S. Aljarboa, Hessa Alduhailan, Faris Almutairi, Raeesa Mohammad, Muhammad Atteya, Iman Hasan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-12-01
Serier:Heliyon
Fag:
Valproate
Indole-3-acetic acid
Chenodeoxycholic acid
Nrf2/HO-1
Cytoglobin
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024171009
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