Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration

Abstract A link between chronic stress and Parkinson’s disease (PD) pathogenesis is emerging. Ample evidence demonstrates that the presynaptic neuronal protein alpha-synuclein (asyn) is closely tied to PD pathogenesis. However, it is not known whether stress system dysfunction is present in PD, if a...

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Detalhes bibliográficos

Principais autores:	Modestos Nakos Bimpos, Katerina Karali, Christine Antoniou, Dionysios Palermos, Maria Fouka, Anastasios Delis, Iason Tzieras, George Panagiotis Chrousos, Yassemi Koutmani, Leonidas Stefanis, Alexia Polissidis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-06-01
Colecção:	Acta Neuropathologica Communications
Assuntos:	Parkinson’s disease Alpha-synuclein Corticosterone HPA axis Glucocorticoids Chronic stress
Acesso em linha:	https://doi.org/10.1186/s40478-024-01797-w
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