Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain

Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed a systems pharmacology model of intracellular signaling in peripheral neurons to identify novel drug targets for preven...

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Principais autores:	Peter Bloomingdale, Cristina Meregalli, Kevin Pollard, Annalisa Canta, Alessia Chiorazzi, Giulia Fumagalli, Laura Monza, Eleonora Pozzi, Paola Alberti, Elisa Ballarini, Norberto Oggioni, Louise Carlson, Wensheng Liu, Mehrnoosh Ghandili, Tracey A. Ignatowski, Kelvin P. Lee, Michael J. Moore, Guido Cavaletti, Donald E. Mager
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-01-01
coleção:	Frontiers in Pharmacology
Assuntos:	bortezomib dexanabinol multiple myeloma peripheral neuropathy pharmacodynamics systems pharmacology
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2021.817236/full
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