Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing

The functional significance of start site choice in promoter architectures is little understood. Here the authors identify in zebrafish development and mammalian cells a class of dual-initiation promoters, in which non-canonical YC dinucleotides reflecting 5’-TOP/TCT initiation are intertwined with...

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Bibliografiska uppgifter

Huvudupphov:	Chirag Nepal, Yavor Hadzhiev, Piotr Balwierz, Estefanía Tarifeño-Saldivia, Ryan Cardenas, Joseph W. Wragg, Ana-Maria Suzuki, Piero Carninci, Bernard Peers, Boris Lenhard, Jesper B. Andersen, Ferenc Müller
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2020-01-01
Serie:	Nature Communications
Länkar:	https://doi.org/10.1038/s41467-019-13687-0
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